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It significantly ameliorates high-fat diet-induced structural dysbiosis of the gut microbiota by reducing the abundance of harmful bacteria positively correlated with hepatic lipid deposition (e.g., Lachnospiraceae and Collinsella) and increasing the abundance of beneficial bacteria (e.g., Ruminococcus and Turicibacter), thereby reducing hepatic lipogenesis and ultimately alleviates liver steatosis and lipid accumulation (Wang S

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Additionally, SIRT3 deacetylates ceramide synthases, promoting ceramide accumulation and inhibiting complex III activity 184

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Cypermethrin induces cell injury in primary cortical neurons of C57BL/6 mice by inhibiting Nrf2/ARE signaling pathway